[18f]olaparib

`[18f]olaparib` is an investigational radiopharmaceutical PET tracer developed by the Universitair Medisch Centrum Groningen (UMCG) for the non-invasive assessment of Poly (ADP-ribose) polymerase (PARP) expression in tumors. As a fluorine-18 labeled analog of the clinical PARP inhibitor olaparib, it retains high binding affinity for PARP1 and PARP2 enzymes. These enzymes are critical for DNA damage repair and are frequently overexpressed in various cancers, including head and neck squamous cell carcinoma (HNSCC). By utilizing Positron Emission Tomography (PET) imaging, `[18f]olaparib` enables the quantification of PARP density in vivo, which may serve as a predictive biomarker for identifying patients likely to respond to PARP inhibitor therapy and for monitoring therapeutic efficacy or target engagement.

Other names

Fluorine-18 olaparibFluorine18 olaparibFluorine 18 olaparib